NFL Week 2 Outlook and 15 Score Predictions

One Week 2 result is already final The official NFL Week 2 schedule contains 16 games. This outlook was prepared on September 20, 2026, at 8:08 AM Eastern, before the Sunday slate began. Scores list the away team first and the home team second.[1] Detroit Lions at Buffalo Bills. Completed result. Buffalo won 41 to 31 on Thursday night. This is a recorded result, not a retroactive prediction. The NFL Game Center and official game book confirm the final score.[2] [3] The remaining 15 games are pregame straight up winner calls. Confidence applies to the winner, not exact score precision. Injuries, final inactive lists, weather, and late market changes can still alter each matchup. Sunday early game predictions Carolina Panthers at Atlanta Falcons. Straight up winner: Carolina Panthers. Projected score: Carolina 24, Atlanta 20. Confidence: 3/5. Carolina enters with the clearer quarterback outlook, while Atlanta has Michael Penix Jr. ruled out and Tua Tagovailoa listed doubtful. The Panthers still need to control Bijan Robinson after allowing 291 rushing yards in Week 1.[4] [5] New Orleans Saints at Baltimore Ravens. Straight up winner: Baltimore Ravens. Projected score: New Orleans 20, Baltimore 28. Confidence: 3/5. Baltimore produced 506 yards in its opener, and Derrick Henry presents another difficult rushing assignment for New Orleans. Injuries to Zay Flowers and Nnamdi Madubuike cap the confidence.[4] [5] Minnesota Vikings at Chicago Bears. Straight up winner: Chicago Bears. Projected score: Minnesota 20, Chicago 27. Confidence: 3/5. Minnesota will start Carson Wentz because Kyler Murray is out with a concussion. Chicago scored 59 points and ran for 291 yards in Week 1.[4] [5] Cincinnati Bengals at Houston Texans. Straight up winner: Cincinnati Bengals. Projected score: Cincinnati 27, Houston 23. Confidence: 2/5. Joe Burrow remained questionable after a full Friday practice. Houston will be without Nico Collins, its Week 1 leader in receiving production.[4] [5] Pittsburgh Steelers at New England Patriots. Straight up winner: Pittsburgh Steelers. Projected score: Pittsburgh 20, New England 17. Confidence: 2/5. Pittsburgh's defense opened with four sacks and two interceptions, while Drake Maye threw three interceptions in New England's loss. Injuries on both rosters keep the margin narrow.[4] [5] Green Bay Packers at New York Jets. Straight up winner: Green Bay Packers. Projected score: Green Bay 24, New York 20. Confidence: 3/5. Jordan Love threw for 387 yards and Christian Watson reached 147 receiving yards in Week 1. Green Bay's protection concerns keep this close.[4] [5] Cleveland Browns at Tampa Bay Buccaneers. Straight up winner: Tampa Bay Buccaneers. Projected score: Cleveland 16, Tampa Bay 24. Confidence: 3/5. Cleveland allowed five sacks in Week 1 and will again be without guard Teven Jenkins. Tampa Bay's home offense gets the stronger matchup.[4] [5] Philadelphia Eagles at Tennessee Titans. Straight up winner: Philadelphia Eagles. Projected score: Philadelphia 27, Tennessee 17. Confidence: 3/5. Tennessee allowed 152 rushing yards on 39 carries in Week 1. That gives Saquon Barkley and Jalen Hurts a clear possession path.[4] [5] Sunday late and prime time predictions Jacksonville Jaguars at Denver Broncos. Straight up winner: Jacksonville Jaguars. Projected score: Jacksonville 24, Denver 20. Confidence: 3/5. Jacksonville opened with a 34 to 10 win and four touchdown passes from Trevor Lawrence. Denver's Week 1 tackling problems give Jacksonville the narrow edge.[4] [5] Las Vegas Raiders at Los Angeles Chargers. Straight up winner: Los Angeles Chargers. Projected score: Las Vegas 20, Los Angeles 24. Confidence: 3/5. Las Vegas generated five sacks in Week 1. Brock Bowers is doubtful for the Raiders, while Ladd McConkey is questionable for the Chargers.[4] [5] Seattle Seahawks at Arizona Cardinals. Straight up winner: Seattle Seahawks. Projected score: Seattle 20, Arizona 17. Confidence: 2/5. Sam Darnold is out, and Drew Lock will start after completing 16 of 22 passes without a turnover in relief. Arizona's 393 opening week yards keep this to a slight road lean.[4] [5] Washington Commanders at Dallas Cowboys. Straight up winner: Dallas Cowboys. Projected score: Washington 24, Dallas 27. Confidence: 2/5. Washington is missing Frankie Luvu and Chig Okonkwo. Dallas also allowed 165 rushing yards in Week 1, which keeps the home call close.[4] [5] Miami Dolphins at San Francisco 49ers. Straight up winner: San Francisco 49ers. Projected score: Miami 16, San Francisco 27. Confidence: 4/5. San Francisco opened with a 27 to 7 win, ran for 174 yards, and did not allow a sack. Miami allowed five sacks and will be without Chop Robinson and Ronnie Harrison.[4] [5] Indianapolis Colts at Kansas City Chiefs. Straight up winner: Kansas City Chiefs. Projected score: Indianapolis 20, Kansas City 27. Confidence: 3/5. Kansas City ran for 220 yards in Week 1, while Indianapolis allowed 202 rushing yards. Chris Jones remains questionable, which keeps the home pick at medium confidence.[4] [5] New York Giants at Los Angeles Rams. Straight up winner: Los Angeles Rams. Projected score: New York 20, Los Angeles 24. Confidence: 3/5. The Rams need a response after scoring seven points in Week 1, and Puka Nacua is questionable. New York's opening win makes this a modest home rebound call.[4] [5] SBA Takeaway Buffalo's 41 to 31 win is a completed Week 2 result and is excluded from the prediction scorecard. The other 15 entries are time stamped pregame forecasts with straight up winners, projected scores, and confidence ratings. The board contains one 4/5 call, ten 3/5 calls, and four 2/5 calls. That distribution reflects a slate with meaningful quarterback and injury uncertainty. My Bet Assist will preserve these forecasts after the games and grade only the straight up winner calls. Exact scores remain projections, not the grading standard. Check final inactive lists and current prices before making any betting decision, and treat every forecast as informational rather than certain. Sources - [1] NFL official 2026 Week 2 schedule - [2] NFL Game Center Lions at Bills - [3] NFL official Lions at Bills game book - [4] NFL Week 2 injury report and player statuses - [5] ESPN Week 2 matchup previews and predictions Related Reading - NFL Week 1 Results: 9 of 14 Winner Calls Correct - Sam Darnold’s Diagnosis Still Needs a Week 2 Check - Good AI Analysis Shows Its Work Before It Shows a Bet